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Ratain, Mark J.
One or more keywords matched the following items that are connected to Ratain, Mark J.
Item TypeName
Concept Complementary Therapies
Concept Transaminases
Concept Carcinoma, Squamous Cell
Concept Antigens, Differentiation, T-Lymphocyte
Concept Cell Count
Concept Bayes Theorem
Concept Pan troglodytes
Concept Carcinoma, Renal Cell
Concept Biological Transport
Concept Blood Transfusion
Concept Carcinoma, Non-Small-Cell Lung
Concept Evaluation Studies as Topic
Concept Combined Modality Therapy
Concept Glutathione Transferase
Concept Decision Support Techniques
Concept Drug Therapy
Concept Tegafur
Concept DNA Topoisomerases, Type II
Concept Diphtheria Toxin
Concept Drug Therapy, Combination
Concept Terminology as Topic
Concept Killer Cells, Natural
Concept DNA Topoisomerases, Type I
Concept Germ Cells
Concept Liver Function Tests
Concept Models, Theoretical
Concept Neoplasm Transplantation
Concept Hot Temperature
Concept Patents as Topic
Concept Patient Education as Topic
Concept Kidney Function Tests
Concept Neuropsychological Tests
Concept Pharmacy and Therapeutics Committee
Concept Thrombocytopenia
Concept Thromboembolism
Concept Protein-Tyrosine Kinases
Concept Transcription Factors
Concept Troleandomycin
Concept Triazines
Concept Immunoenzyme Techniques
Concept Research Support as Topic
Concept Soft Tissue Neoplasms
Concept Carcinoma, Merkel Cell
Concept Sensory Receptor Cells
Concept Leukemia, B-Cell
Concept Thiotepa
Concept Thymidine
Concept Bone Marrow Transplantation
Concept Time Factors
Concept Tomography, X-Ray Computed
Concept Transcription, Genetic
Concept Technology, Pharmaceutical
Concept Testicular Neoplasms
Concept Thalidomide
Concept Statistics as Topic
Concept Interferon Type I
Concept Tetrahydrofolates
Concept Thiones
Concept Thionucleotides
Concept Lymphoma, T-Cell, Cutaneous
Concept CHO Cells
Concept Truth Disclosure
Concept Biomarkers, Tumor
Concept Clinical Trials, Phase I as Topic
Concept Practice Guidelines as Topic
Concept Tamoxifen
Concept Thiophenes
Concept Multicenter Studies as Topic
Concept Leukemia, Lymphocytic, Chronic, B-Cell
Concept Thyroxine
Concept Hematopoietic Stem Cell Transplantation
Concept Randomized Controlled Trials as Topic
Concept Reverse Transcriptase Polymerase Chain Reaction
Concept Tumor Cells, Cultured
Concept Treatment Refusal
Concept Myosin Type II
Concept Salvage Therapy
Concept Leukemia, Prolymphocytic
Concept Lymphocytes, Tumor-Infiltrating
Concept Clinical Trials, Phase II as Topic
Concept Therapies, Investigational
Concept Protein Structure, Tertiary
Concept Treatment Outcome
Concept Tissue Fixation
Concept Guidelines as Topic
Concept Gene Transfer Techniques
Concept Cell Proliferation
Concept Neoplasms, Squamous Cell
Concept Receptor Protein-Tyrosine Kinases
Concept Biomedical Technology
Concept Alkyl and Aryl Transferases
Concept Venous Thromboembolism
Concept Collagen Type I
Concept Molecular Diagnostic Techniques
Concept Topoisomerase I Inhibitors
Concept Therapeutic Human Experimentation
Concept Equilibrative Nucleoside Transporter 1
Concept Trust
Concept Tumor Burden
Concept Carcinoma, Small Cell
Concept Technology Transfer
Concept Cell Cycle Proteins
Concept Periodicals as Topic
Concept Organic Anion Transporters, Sodium-Independent
Concept Portraits as Topic
Concept Tandem Mass Spectrometry
Concept Taiwan
Concept Tea
Concept Testosterone
Concept Therapeutic Equivalency
Concept Tissue Distribution
Concept Taxoids
Concept Molecular Targeted Therapy
Concept Triazoles
Concept TOR Serine-Threonine Kinases
Concept High-Throughput Nucleotide Sequencing
Concept Genotyping Techniques
Concept Human Umbilical Vein Endothelial Cells
Concept Adaptor Proteins, Signal Transducing
Concept NFATC Transcription Factors
Concept Life Tables
Concept Thiosemicarbazones
Concept Thymidylate Synthase
Concept Thyroid Neoplasms
Concept Lymphoma, B-Cell
Concept Transfection
Concept Treatment Failure
Concept Genetic Therapy
Concept Topoisomerase Inhibitors
Concept Platelet Transfusion
Concept ATP-Binding Cassette Transporters
Concept Lymphoma, Large B-Cell, Diffuse
Concept Clinical Trials, Phase III as Topic
Concept Precursor Cell Lymphoblastic Leukemia-Lymphoma
Concept Topotecan
Concept Withholding Treatment
Concept Receptor, trkA
Concept Organic Anion Transporters
Concept Tubulin Modulators
Concept Hep G2 Cells
Concept Tumor Microenvironment
Concept Programmed Cell Death 1 Receptor
Concept Cell Line, Tumor
Concept Topoisomerase II Inhibitors
Concept Anemia, Sickle Cell
Concept Biliary Tract
Concept Blood Cell Count
Concept Cell Line
Concept Cell Survival
Concept Cells, Cultured
Concept Clinical Trials as Topic
Concept Genetic Testing
Concept Leukemia, Hairy Cell
Concept Predictive Value of Tests
Concept T-Lymphocytes
Concept Thymine
Concept Tramadol
Concept Translocation, Genetic
Concept Signal Transduction
Concept Transcriptional Activation
Concept Erythrocyte Transfusion
Concept Neuroendocrine Tumors
Concept Toxicity Tests
Concept Maximum Tolerated Dose
Concept Membrane Transport Proteins
Concept Organic Cation Transporter 1
Concept Quantitative Trait Loci
Concept Transforming Growth Factor beta3
Academic Article Rapid response of B-cell prolymphocytic leukemia to 2-chlorodeoxyadenosine.
Academic Article Statistical and ethical issues in the design and conduct of phase I and II clinical trials of new anticancer agents.
Academic Article Phase I clinical and pharmacology study of 502U83 given as a 24-h continuous intravenous infusion.
Academic Article Phase I study of escalating doses of mitoxantrone and paclitaxel with granulocyte-macrophage colony stimulating factor support.
Academic Article Model-guided determination of maximum tolerated dose in phase I clinical trials: evidence for increased precision.
Academic Article Cisplatin, fluorouracil, and leucovorin augmented by interferon alfa-2b in head and neck cancer: a clinical and pharmacologic analysis.
Academic Article Interleukin-2 fusion protein: an investigational therapy for interleukin-2 receptor expressing malignancies.
Academic Article Phase I study of suramin administered by intermittent infusion without adaptive control to cancer patients: update of two expanded dose levels near the maximally tolerated dose.
Academic Article Dose-escalation trial of cladribine using five daily intravenous infusions in patients with advanced hematologic malignancies.
Academic Article Keratoacanthomas and skin neoplasms associated with suramin therapy.
Academic Article Mineralocorticoid insufficiency due to suramin therapy.
Academic Article Pharmacodynamics of fluorouracil-based induction chemotherapy in advanced head and neck cancer.
Academic Article Treatment-related fatal sepsis from topotecan/cisplatin and topotecan/paclitaxel.
Academic Article Limited-sampling models for irinotecan pharmacokinetics-pharmacodynamics: prediction of biliary index and intestinal toxicity.
Academic Article Therapeutic relevance of pharmacokinetics and pharmacodynamics.
Academic Article Ethical issues in phase I oncology research: a comparison of investigators and institutional review board chairpersons.
Academic Article Data modifications to phase I study of suramin.
Academic Article New phase I trial methodology.
Academic Article Learning from our patients: one participant's impact on clinical trial research and informed consent.
Academic Article Pharmacokinetic and pharmacodynamic evaluation of the topoisomerase inhibitor irinotecan in cancer patients.
Academic Article Study of cohort-specific consent and patient control in phase I cancer trials.
Academic Article A phase II study of 9-aminocamptothecin in advanced non-small-cell lung cancer.
Academic Article Phase I study of concomitant chemoradiotherapy with paclitaxel, fluorouracil, and hydroxyurea with granulocyte colony-stimulating factor support for patients with poor-prognosis cancer of the head and neck.
Academic Article Phase I trial of a ligand fusion-protein (DAB389IL-2) in lymphomas expressing the receptor for interleukin-2.
Academic Article Evaluation of neuropathy in patients on suramin treatment.
Academic Article Phase I study of treatment with oral 13-cis-retinoic acid, subcutaneous interferon alfa-2a, cisplatin, and 24-hour infusion 5-fluorouracil/leucovorin.
Academic Article Promising new agents in oncologic treatment.
Academic Article Pharmacokinetics and pharmacodynamics of oltipraz as a chemopreventive agent.
Academic Article Phase II trial of paclitaxel and topotecan with granulocyte colony-stimulating factor support in stage IV breast cancer.
Academic Article Oral chemotherapy: rationale and future directions.
Academic Article New perspectives on the toxicity of etoposide.
Academic Article Thymidylate synthase expression and response to neoadjuvant chemotherapy in patients with advanced head and neck cancer.
Academic Article Phase I and pharmacokinetic trial of gemcitabine in patients with hepatic or renal dysfunction: Cancer and Leukemia Group B 9565.
Academic Article Balanced translocations involving chromosome bands 11q23 and 21q22 in therapy-related leukemia.
Academic Article Phenotype-genotype correlation of in vitro SN-38 (active metabolite of irinotecan) and bilirubin glucuronidation in human liver tissue with UGT1A1 promoter polymorphism.
Academic Article Granulocyte-macrophage--colony stimulating factor in metastatic renal cell carcinoma: a phase II trial.
Academic Article Pharmacokinetics and pharmacodynamics of 9-aminocamptothecin infused over 72 hours in phase II studies.
Academic Article O6-benzylguanine in humans: metabolic, pharmacokinetic, and pharmacodynamic findings.
Academic Article Phase I and pharmacokinetic trial of paclitaxel in patients with hepatic dysfunction: Cancer and Leukemia Group B 9264.
Academic Article Phase I study of ZD9331 on short daily intravenous bolus infusion for 5 days every 3 weeks with fixed dosing recommendations.
Academic Article Gazing into a crystal ball-cancer therapy in the post-genomic era.
Academic Article Screening for sources of interindividual pharmacokinetic variability in anticancer drug therapy: utility of population analysis.
Academic Article Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer.
Academic Article Chronic daily low dose of 4-methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione (Oltipraz) in patients with previously resected colon polyps and first degree female relatives of breast cancer patients.
Academic Article Phase I and pharmacologic study of continuous infusion topotecan in combination with cisplatin in patients with advanced cancer: a Cancer and LeukemiaGroup B study.
Academic Article Development of target-based antineoplastic agents.
Academic Article Flavopiridol metabolism in cancer patients is associated with the occurrence of diarrhea.
Academic Article Rationale for phase I study of UFT plus leucovorin and oral JM-216.
Academic Article Pharmacology of 21-day oral etoposide given in combination with i.v. cisplatin in patients with extensive-stage small cell lung cancer: a cancer and leukemia group B study (CALGB 9062).
Academic Article Limited sampling model for area under the concentration time curve of total topotecan.
Academic Article Pharmacogenetics and cancer chemotherapy.
Academic Article Quantitative analysis of ethical issues in phase I trials: a survey interview of 144 advanced cancer patients.
Academic Article A phase I study of oral uracil/ftorafur (UFT) plus leucovorin and bis-acetato-ammine-dichloro-cyclohexylamine-platinum IV (JM-216) each given over 14 days every 28 days.
Academic Article Pharmacogenetics in cancer etiology and chemotherapy.
Academic Article Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer.
Academic Article Antitumor activity of DAB389IL-2 fusion toxin in mycosis fungoides.
Academic Article Anticancer agents targeting signaling molecules and cancer cell environment: challenges for drug development?
Academic Article A Phase I study of raltitrexed and paclitaxel given every 3 weeks to patients with solid tumors.
Academic Article Dear doctor: we really are not sure what dose of capecitabine you should prescribe for your patient.
Academic Article Estimation of the effect of food on the disposition of oral 5-fluorouracil in combination with eniluracil.
Academic Article Irinotecan dosing: does the CPT in CPT-11 stand for "Can't Predict Toxicity"?
Academic Article Update on pharmacogenetics in cancer chemotherapy.
Academic Article 5-Fluorouracil, leucovorin, hydroxyurea, and escalating doses of continuous-infusion cisplatin with concomitant radiotherapy: a clinical and pharmacologic study.
Academic Article UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity.
Academic Article A phase I study of suramin with once- or twice-monthly dosing in patients with advanced cancer.
Academic Article Endostatin: are the 2 years up yet?
Academic Article Pharmacogenetics: a tool for individualizing antineoplastic therapy.
Academic Article Conflict-of-interest policies.
Academic Article Phase I clinical and pharmacogenetic study of weekly TAS-103 in patients with advanced cancer.
Academic Article Anticancer drug discovery and development throughout the world.
Academic Article Troxacitabine in patients with refractory leukemia.
Academic Article Determination of the optimal modulatory dose of O6-benzylguanine in patients with surgically resectable tumors.
Academic Article Randomized study of three different doses of suramin administered with a fixed dosing schedule in patients with advanced prostate cancer: results of intergroup 0159, cancer and leukemia group B 9480.
Academic Article A phase I study of liposomal doxorubicin (Doxil) with topotecan.
Academic Article Interethnic difference in the allelic distribution of human epidermal growth factor receptor intron 1 polymorphism.
Academic Article Pharmacogenetics in cancer treatment.
Academic Article Phase I study of pegylated liposomal doxorubicin, paclitaxel, and cisplatin in patients with advanced solid tumors.
Academic Article Five-day infusion of fluorodeoxyuridine with high-dose oral leucovorin: a phase I study.
Academic Article Dose-escalating study of capecitabine plus gemcitabine combination therapy in patients with advanced cancer.
Academic Article Serum soluble interleukin-2 receptor is associated with clinical and pathologic disease status in hairy cell leukemia.
Academic Article Phase I clinical and pharmacokinetic study of protein kinase C-alpha antisense oligonucleotide ISIS 3521 administered in combination with 5-fluorouracil and leucovorin in patients with advanced cancer.
Academic Article A pharmacogenetic study of uridine diphosphate-glucuronosyltransferase 2B7 in patients receiving morphine.
Academic Article Phase I-II trial of erythropoietin in the treatment of cisplatin-associated anemia.
Academic Article Correspondence re: Raida, M. et al., prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls.
Academic Article Phase I study to evaluate multiple regimens of intravenous 5-fluorouracil administered in combination with weekly gemcitabine in patients with advanced solid tumors: a potential broadly active regimen for advanced solid tumor malignancies.
Academic Article Population pharmacokinetic model for irinotecan and two of its metabolites, SN-38 and SN-38 glucuronide.
Academic Article Biliary transport of irinotecan and metabolites in normal and P-glycoprotein-deficient mice.
Academic Article In vitro characterization of hepatic flavopiridol metabolism using human liver microsomes and recombinant UGT enzymes.
Academic Article Hairy cell leukaemia: the role of alpha interferon.
Academic Article Pharmacogenomics: road to anticancer therapeutics nirvana?
Academic Article Estimation of the glomerular filtration rate in cancer patients: a new formula for new drugs.
Academic Article Relationship of baseline serum bilirubin to efficacy and toxicity of single-agent irinotecan in patients with metastatic colorectal cancer.
Academic Article Clinical trial designs for cytostatic agents.
Academic Article Paradoxical relationship between acetylator phenotype and amonafide toxicity.
Academic Article Phase I clinical trial of CEP-2563 dihydrochloride, a receptor tyrosine kinase inhibitor, in patients with refractory solid tumors.
Academic Article Treatment of chemotherapy-induced anemia with recombinant human erythropoietin in cancer patients.
Academic Article "Irinogenetics" and UGT1A: from genotypes to haplotypes.
Academic Article A phase I trial of pharmacokinetic modulation of carboxyamidotriazole (CAI) with ketoconazole in patients with advanced cancer.
Academic Article A phase I study of cantuzumab mertansine administered as a single intravenous infusion once weekly in patients with advanced solid tumors.
Academic Article Dose-ranging study of the safety and pharmacokinetics of atrasentan in patients with refractory malignancies.
Academic Article Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan.
Academic Article Randomized discontinuation design: application to cytostatic antineoplastic agents.
Academic Article Haplotype structure of the UDP-glucuronosyltransferase 1A1 promoter in different ethnic groups.
Academic Article A phase I trial of escalating doses of trastuzumab combined with daily subcutaneous interleukin 2: report of cancer and leukemia group B 9661.
Academic Article A phase I trial of gemcitabine plus cladribine in patients with advanced hematologic malignant diseases.
Academic Article A phase I study of the oral combination of CI-994, a putative histone deacetylase inhibitor, and capecitabine.
Academic Article Weekly, high-dose paclitaxel in advanced lung carcinoma: a phase II study with pharmacokinetics by the Cancer and Leukemia Group B.
Academic Article Irinotecan treatment in cancer patients with UGT1A1 polymorphisms.
Academic Article UGT pharmacogenomics: implications for cancer risk and cancer therapeutics.
Academic Article Successful implementation of the randomized discontinuation trial design: an application to the study of the putative antiangiogenic agent carboxyaminoimidazole in renal cell carcinoma--CALGB 69901.
Academic Article Modulation of irinotecan with cyclosporine: a phase II trial in advanced colorectal cancer.
Academic Article Pharmacokinetic variability of anticancer agents.
Academic Article Delivery of a liposomal c-raf-1 antisense oligonucleotide by weekly bolus dosing in patients with advanced solid tumors: a phase I study.
Academic Article Pharmacokinetics, pharmacodynamics and adherence to oral topotecan in myelodysplastic syndromes: a Cancer and Leukemia Group B study.
Academic Article Phase II oncology trials: let's be positive.
Academic Article Randomized phase II trials and prostate-specific antigen endpoints in prostate cancer: much ado about nothing?
Academic Article Personalized medicine: building the GPS to take us there.
Academic Article A comparison of the pharmacokinetics and pharmacodynamics of docetaxel between African-American and Caucasian cancer patients: CALGB 9871.
Academic Article Global gene expression as a function of germline genetic variation.
Academic Article From bedside to bench to bedside to clinical practice: an odyssey with irinotecan.
Academic Article Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis.
Academic Article Response to high dose cyclophosphamide with GM-CSF in Merkel cell tumor.
Academic Article Heritability and linkage analysis of sensitivity to cisplatin-induced cytotoxicity.
Academic Article Clarification regarding "phase II trials published in 2002: a cross-specialty comparison showing significant design differences between oncology trials and other medical specialties" and the accompanying commentary, "phase II cancer trials: out of control?".
Academic Article Relationship of EGFR mutations, expression, amplification, and polymorphisms to epidermal growth factor receptor inhibitors in the NCI60 cell lines.
Academic Article Finding the right dose.
Academic Article Irinogenetics: what is the right star?
Academic Article Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma.
Academic Article Inflammation of actinic keratoses subsequent to therapy with sorafenib, a multitargeted tyrosine-kinase inhibitor.
Academic Article Interpreting disparate responses to cancer therapy: the role of human population genetics.
Academic Article Effects of green tea compounds on irinotecan metabolism.
Academic Article Terminal ballistics of kinase inhibitors: there are no magic bullets.
Academic Article Phase I study of inhaled Doxorubicin for patients with metastatic tumors to the lungs.
Academic Article Phase II trials published in 2002: a cross-specialty comparison showing significant design differences between oncology trials and other medical specialties.
Academic Article Searching for tissue-specific expression pattern-linked nucleotides of UGT1A isoforms.
Academic Article Lack of association between common polymorphisms in UGT1A9 and gene expression and activity.
Academic Article The role of SN-38 exposure, UGT1A1*28 polymorphism, and baseline bilirubin level in predicting severe irinotecan toxicity.
Academic Article The pharmacogenetics research network: from SNP discovery to clinical drug response.
Academic Article Inside information: Financial conflicts of interest for research subjects in early phase clinical trials.
Academic Article Interpreting P values in pharmacogenetic studies: a call for process and perspective.
Academic Article CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.
Academic Article Pharmacogenomic and pharmacokinetic determinants of erlotinib toxicity.
Academic Article The value meal: how to save $1,700 per month or more on lapatinib.
Academic Article A Phase II trial of suramin monthly x 3 for hormone-refractory prostate carcinoma.
Academic Article Modeling interpatient pharmacodynamic variability of etoposide.
Academic Article Design of phase II cancer trials using a continuous endpoint of change in tumor size: application to a study of sorafenib and erlotinib in non small-cell lung cancer.
Academic Article Phase II studies of modern drugs directed against new targets: if you are fazed, too, then resist RECIST.
Academic Article Phase I trial of orally administered CEP-701, a novel neurotrophin receptor-linked tyrosine kinase inhibitor.
Academic Article Biomarkers in early cancer drug development: limited utility.
Academic Article Prediction of CYP3A4 enzyme activity using haplotype tag SNPs in African Americans.
Academic Article Genomic assessment of a multikinase inhibitor, sorafenib, in a rodent model of pulmonary hypertension.
Academic Article Genome-wide identification of genetic determinants for the cytotoxicity of perifosine.
Academic Article Exploring the relationship between polymorphic (TG/CA)n repeats in intron 1 regions and gene expression.
Academic Article Evaluation of Leu-M5 (CD11c) in hairy cell leukemia by the alkaline phosphatase anti-alkaline phosphatase technique.
Academic Article A phase I trial to determine the safety, tolerability, and maximum tolerated dose of deforolimus in patients with advanced malignancies.
Academic Article EGFR pharmacogenomics: the story continues to mutate and evolve.
Academic Article A phase I study of antisense oligonucleotide GTI-2040 given by continuous intravenous infusion in patients with advanced solid tumors.
Academic Article The Werner's syndrome 4330T>C (Cys1367Arg) gene variant does not affect the in vitro cytotoxicity of topoisomerase inhibitors and platinum compounds.
Academic Article Dynamic contrast-enhanced magnetic resonance imaging pharmacodynamic biomarker study of sorafenib in metastatic renal carcinoma.
Academic Article Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301.
Academic Article Recent advances in the treatment of hairy-cell leukemia.
Academic Article R(+)XK469 inhibits hydroxylation of S-warfarin by CYP2C9.
Academic Article Sequential treatment of hairy cell leukemia: a new role for interferon.
Academic Article Etoposide pathway.
Academic Article Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan.
Academic Article Pharmacologically based dosing of etoposide: a means of safely increasing dose intensity.
Academic Article Comparison of the drug-drug interactions potential of erlotinib and gefitinib via inhibition of UDP-glucuronosyltransferases.
Academic Article Hairy cell leukemia. Current management.
Academic Article The cancer and leukemia group B pharmacology and experimental therapeutics committee: a historical perspective.
Academic Article The design of phase II clinical trials testing cancer therapeutics: consensus recommendations from the clinical trial design task force of the national cancer institute investigational drug steering committee.
Academic Article Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents.
Academic Article Ambulatory monitoring detects sorafenib-induced blood pressure elevations on the first day of treatment.
Academic Article A dosing/cross-development study of the multikinase inhibitor sorafenib in patients with pulmonary arterial hypertension.
Academic Article Vascular endothelial growth factor pathway.
Academic Article Testing the wrong hypothesis in phase II oncology trials: there is a better alternative.
Academic Article Other paradigms: better treatments are identified by better trials: the value of randomized phase II studies.
Academic Article Evaluating the activity of temsirolimus in neuroendocrine cancer.
Academic Article Cancer pharmacogenomics and pharmacoepidemiology: setting a research agenda to accelerate translation.
Academic Article Complementary and alternative medicine among advanced cancer patients enrolled on phase I trials: a study of prognosis, quality of life, and preferences for decision making.
Academic Article In vitro and in vivo oxidative metabolism and glucuronidation of anastrozole.
Academic Article Phase I and pharmacokinetic study of erlotinib for solid tumors in patients with hepatic or renal dysfunction: CALGB 60101.
Academic Article Attitudes toward research participation and investigator conflicts of interest among advanced cancer patients participating in early phase clinical trials.
Academic Article A phase I study of continuous infusion cilengitide in patients with solid tumors.
Academic Article A phase I study of sirolimus and bevacizumab in patients with advanced malignancies.
Academic Article Biomarkers in phase I oncology trials: signal, noise, or expensive distraction?
Academic Article Phase I study of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde-thiosemicarbazone (3-AP) in combination with high dose cytarabine in patients with advanced myeloid leukemia.
Academic Article The effect of thalidomide on the pharmacokinetics of irinotecan and metabolites in advanced solid tumor patients.
Academic Article Prospective evaluation of body surface area as a determinant of paclitaxel pharmacokinetics and pharmacodynamics in women with solid tumors: Cancer and Leukemia Group B Study 9763.
Academic Article A functional common polymorphism in a Sp1 recognition site of the epidermal growth factor receptor gene promoter.
Academic Article Recommended changes to oncology clinical trial design: revolution or evolution?
Academic Article The investigational drug steering committee.
Academic Article Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue.
Academic Article Ethical, scientific, and regulatory perspectives regarding the use of placebos in cancer clinical trials.
Academic Article What is the choice of treatment for hairy cell leukemia?
Academic Article Flushing oral oncology drugs down the toilet.
Academic Article A genome-wide association study identifies novel loci for paclitaxel-induced sensory peripheral neuropathy in CALGB 40101.
Academic Article Re: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial.
Academic Article Models of excellence: improving oncology drug development.
Academic Article Adaptive control of etoposide administration: impact of interpatient pharmacodynamic variability.
Academic Article Why RECIST works and why it should stay--reply to counterpoint.
Academic Article Alpha-2 interferon therapy of hairy-cell leukemia: a multicenter study of 64 patients.
Academic Article Pharmacokinetics and pharmacodynamics of long-term continuous-infusion doxorubicin.
Academic Article Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer.
Academic Article Nonprofit biomedical companies.
Academic Article Correspondence re: Xiu F. Hu et al., Combined use of cyclosporin A and verapamil in modulating multidrug resistance in human leukemia cell lines. Cancer Res., 50: 2953-2957, 1990.
Academic Article Randomized study of the duration of treatment with interferon alfa-2B in patients with hairy cell leukemia.
Academic Article Limited sampling models for doxorubicin pharmacokinetics.
Academic Article Optimising the design of phase II oncology trials: the importance of randomisation.
Academic Article Interferon treatment for hairy cell leukemia. An update on a cohort of 69 patients treated from 1983 to 1986.
Academic Article Phase I study of escalating does of carboplatin.
Academic Article Prognostic factors for survival in patients treated in phase I clinical trials.
Academic Article Statistical approaches to pharmacodynamic modeling: motivations, methods, and misperceptions.
Academic Article Phase I trial of granulocyte-macrophage colony-stimulating factor plus high-dose cyclophosphamide given every 2 weeks: a Cancer and Leukemia Group B study.
Academic Article Changes in peripheral blood and bone marrow specimens following therapy with recombinant alpha 2 interferon for hairy cell leukemia.
Academic Article Bar the windows but open the door to randomization.
Academic Article Resampling phase III data to assess phase II trial designs and endpoints.
Academic Article Treatment of hairy cell leukemia with recombinant alpha 2 interferon.
Academic Article A randomized study of inpatient versus outpatient continuous infusion chemotherapy for patients with locally advanced head and neck cancer.
Academic Article Relapse after interferon alfa-2b therapy for hairy-cell leukemia: analysis of prognostic variables.
Academic Article A programmable and implantable pumping system for systemic chemotherapy: a performance analysis in 52 patients.
Academic Article A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
Academic Article Sequential evaluation of alpha-2b-interferon treatment in 128 patients with hairy cell leukemia.
Academic Article Durability of responses to interferon alfa-2b in advanced hairy cell leukemia.
Academic Article The 1200 patients project: creating a new medical model system for clinical implementation of pharmacogenomics.
Academic Article Inconsistent labeling of food effect for oral agents across therapeutic areas: differences between oncology and non-oncology products.
Academic Article Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.
Academic Article Encephalopathy is the dose-limiting toxicity of intravenous hepsulfam: results of a phase I trial in patients with advanced hematological malignancies.
Academic Article Merrill Jon Egorin, MD, 1948-2010.
Academic Article Functional EGFR germline polymorphisms may confer risk for EGFR somatic mutations in non-small cell lung cancer, with a predominant effect on exon 19 microdeletions.
Academic Article The role of interferon in the treatment of hairy cell leukemia.
Academic Article TPMT, UGT1A1 and DPYD: genotyping to ensure safer cancer therapy?
Academic Article The treatment of hairy cell leukemia: an update.
Academic Article Randomized phase II trials: a long-term investment with promising returns.
Academic Article Germline pharmacogenomics in oncology: decoding the patient for targeting therapy.
Academic Article Pushing the envelope: informed consent in phase I trials.
Academic Article Pharmacogenomics and patient care: one size does not fit all.
Academic Article Sequential therapy with dacarbazine and carmustine: a phase I study.
Academic Article Phase I trial of a genetically engineered interleukin-2 fusion toxin (DAB486IL-2) as a 6 hour intravenous infusion in patients with hematologic malignancies.
Academic Article Human pharmacokinetics, excretion, and metabolism of the anthracycline antibiotic menogaril (7-OMEN, NSC 269148) and their correlation with clinical toxicities.
Academic Article Phase I study of suramin given by intermittent infusion without adaptive control in patients with advanced cancer.
Academic Article Report of a multi-institutional study of 193 patients with hairy cell leukemia treated with interferon-alfa2b.
Academic Article Therapy-related acute myeloid leukemia secondary to inhibitors of topoisomerase II: from the bedside to the target genes.
Academic Article Hydroxyurea and etoposide: in vitro synergy and phase I clinical trial.
Academic Article Pharmacodynamic-pharmacokinetic relationships and therapeutic drug monitoring.
Academic Article A phase I study of intermittent infusion cladribine in patients with solid tumors.
Academic Article Phase I and pharmacokinetic study of a new antineoplastic agent: pyrazine diazohydroxide (NSC 361456).
Academic Article Limited sampling model for vinblastine pharmacokinetics.
Academic Article Changes in peripheral blood and bone marrow specimens during and after alpha 2b-interferon therapy for hairy cell leukemia.
Academic Article Phase I clinical and pharmacological study of thymidine (NSC 21548) and cis-diamminedichloroplatinum(II) in patients with advanced cancer.
Academic Article A population model for the leukopenic effect of etoposide.
Academic Article Bootstrap validation of pharmacodynamic models defined via stepwise linear regression.
Academic Article The HapMap Resource is Providing New Insights into Ourselves and its Application to Pharmacogenomics.
Academic Article A phase I and pharmacokinetic study of the quinoxaline antitumour Agent R(+)XK469 in patients with advanced solid tumours.
Academic Article Phase I study of paclitaxel and topotecan in patients with advanced tumors: a cancer and leukemia group B study.
Academic Article Pharmacodynamics and long-term toxicity of etoposide.
Academic Article Pharmacogenetics and pharmacogenomics of anticancer agents.
Academic Article Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.
Academic Article Individualizing dosing of irinotecan.
Academic Article Dose-escalation models for combination phase I trials in oncology.
Academic Article Pharmacokinetic modulation of irinotecan and metabolites by cyclosporin A.
Academic Article Etoposide combined with interferon alfa-2b: novel exploitation of established etoposide pharmacokinetics and pharmacodynamics.
Academic Article Analysis of the yield of phase II combination therapy trials in medical oncology.
Academic Article Low-dose interferon alfa-2b in the treatment of hairy cell leukemia.
Academic Article Acute nonlymphocytic leukemia following etoposide and cisplatin combination chemotherapy for advanced non-small-cell carcinoma of the lung.
Academic Article Might cigarettes be a "smoking gun" to reduce taxane myelotoxicity?
Academic Article RECIST: no longer the sharpest tool in the oncology clinical trials toolbox---point.
Academic Article Hyponatremia and other toxic effects during a phase I trial of recombinant human gamma interferon and vinblastine.
Academic Article Human plasma pharmacokinetics of thiotepa following administration of high-dose thiotepa and cyclophosphamide.
Academic Article Flow cytometry in hairy cell leukemia before and during interferon alfa-2b therapy.
Academic Article Interpatient and intrapatient variability in vinblastine pharmacokinetics.
Academic Article Interferon treatment for hairy cell leukemia: an update on a cohort of 69 patients treated from 1983-1986.
Academic Article Perceptions of cancer patients and their physicians involved in phase I trials.
Academic Article Physician-determined patient risk of toxic effects: impact on enrollment and decision making in phase I cancer trials.
Academic Article Phase II and pharmacodynamic studies of pyrazine diazohydroxide (NSC 361456) in patients with advanced renal and colorectal cancer.
Academic Article Amonafide: An active agent in the treatment of previously untreated advanced breast cancer--a cancer and leukemia group B study (CALGB 8642).
Academic Article Drug combinations: dangerous liaisons or great expectations?
Academic Article Body surface area as a determinant of pharmacokinetics and drug dosing.
Academic Article Phase I study of the combination of losoxantrone and cyclophosphamide in patients with refractory solid tumours.
Academic Article Phase 1 dose escalation study of docetaxel with filgrastim support in patients with advanced solid tumors.
Academic Article Phase I study of an oral formulation of ZD9331 administered daily for 28 days.
Academic Article Phase I and pharmacokinetic study of 24-hour infusion 5-fluorouracil and leucovorin in patients with organ dysfunction.
Academic Article Quality of life impact of three different doses of suramin in patients with metastatic hormone-refractory prostate carcinoma: results of Intergroup O159/Cancer and Leukemia Group B 9480.
Academic Article A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital.
Academic Article Dose-ranging pharmacodynamic study of tipifarnib (R115777) in patients with relapsed and refractory hematologic malignancies.
Academic Article Modulation of vinblastine resistance with cyclosporine: a phase I study.
Academic Article Phase I study of adozelesin administered by 24-hour continuous intravenous infusion.
Academic Article Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic tests.
Academic Article Measuring response in a post-RECIST world: from black and white to shades of grey.
Academic Article The role of pharmacogenetics in cancer therapeutics.
Academic Article Pharmacogenetics of irinotecan: clinical perspectives on the utility of genotyping.
Academic Article Pharmacodynamics in cancer therapy.
Academic Article UGT1A1*28 genotype affects the in-vitro glucuronidation of thyroxine in human livers.
Academic Article Rapamycin: something old, something new, sometimes borrowed and now renewed.
Academic Article Pharmacogenetic pathway analysis of irinotecan.
Academic Article A phase I and pharmacokinetic study of XK469R (NSC 698215), a quinoxaline phenoxypropionic acid derivative, in patients with refractory acute leukemia.
Academic Article Pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 polymorphisms: are we there yet?
Academic Article Duration of response after interferon treatment of hairy cell leukemia.
Academic Article Creating and evaluating genetic tests predictive of drug response.
Academic Article Phase II study of 9-aminocamptothecin in previously treated lymphomas: results of Cancer and Leukemia Group B 9551.
Academic Article Efficacy and safety of sorafenib in a subset of patients with advanced soft tissue sarcoma from a Phase II randomized discontinuation trial.
Academic Article Plasma pharmacokinetics of high-dose oral melphalan in patients treated with trialkylator chemotherapy and autologous bone marrow reinfusion.
Academic Article Inhibition of paracetamol glucuronidation by tyrosine kinase inhibitors.
Academic Article Two drug interaction studies of sirolimus in combination with sorafenib or sunitinib in patients with advanced malignancies.
Academic Article A limited sampling strategy for cyclophosphamide pharmacokinetics.
Academic Article Phase-I trial of Thiotepa, granulocyte-macrophage colony-stimulating factor and prednisone or pentoxifylline in patients with refractory solid tumors.
Academic Article Opportunities and challenges in the development of experimental drug combinations for cancer.
Academic Article Phase I studies of sirolimus alone or in combination with pharmacokinetic modulators in advanced cancer patients.
Academic Article Rapid response to 2'-deoxycoformycin in advanced hairy cell leukemia after failure of interferons alpha and gamma.
Academic Article Prognostic variables in hairy cell leukemia after splenectomy as initial therapy.
Academic Article Skeletal complications in hairy cell leukemia: diagnosis and therapy.
Academic Article Integration of cell line and clinical trial genome-wide analyses supports a polygenic architecture of Paclitaxel-induced sensory peripheral neuropathy.
Academic Article Playing Russian roulette with tyrosine kinase inhibitors.
Academic Article Evaluation of food effect on pharmacokinetics of vismodegib in advanced solid tumor patients.
Academic Article Cancer pharmacogenomics: strategies and challenges.
Academic Article A novel fully automated molecular diagnostic system (AMDS) for colorectal cancer mutation detection.
Academic Article A genome-wide integrative study of microRNAs in human liver.
Academic Article CYP2D6 genotype and tamoxifen activity: understanding interstudy variability in methodological quality.
Academic Article Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751.
Academic Article Estimation of renal cell carcinoma treatment effects from disease progression modeling.
Academic Article Time to tumor growth: a model end point and new metric system for oncology clinical trials.
Academic Article The relationship of polymorphisms in ABCC2 and SLCO1B3 with docetaxel pharmacokinetics and neutropenia: CALGB 60805 (Alliance).
Academic Article Genome-wide interrogation of longitudinal FEV1 in children with asthma.
Academic Article Sorafenib dose escalation is not uniformly associated with blood pressure elevations in normotensive patients with advanced malignancies.
Academic Article Effects of vascular endothelial growth factor signaling inhibition on human erythropoiesis.
Academic Article Estimation of Progression-Free Survival for All Treated Patients in the Randomized Discontinuation Trial Design.
Academic Article Phase I dose-escalation study of onartuzumab as a single agent and in combination with bevacizumab in patients with advanced solid malignancies.
Academic Article Design of phase I combination trials: recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee.
Academic Article UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers.
Academic Article Targeted therapies: redefining the primary objective of phase I oncology trials.
Academic Article Meaningful use of pharmacogenetics.
Academic Article Bevacizumab and the risk of arterial and venous thromboembolism in patients with metastatic, castration-resistant prostate cancer treated on Cancer and Leukemia Group B (CALGB) 90401 (Alliance).
Academic Article Effect of age on the pharmacokinetics of busulfan in patients undergoing hematopoietic cell transplantation; an alliance study (CALGB 10503, 19808, and 100103).
Academic Article Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of Pazopanib.
Academic Article Tumour heterogeneity in the clinic.
Academic Article Evaluation of utility of pharmacokinetic studies in phase I trials of two oncology drugs.
Academic Article Incorporating biomarkers into drug labeling.
Academic Article Hepatocyte nuclear factor 1 regulates the expression of the organic cation transporter 1 via binding to an evolutionary conserved region in intron 1 of the OCT1 gene.
Academic Article Challenges in interpreting the evidence for genetic predictors of ototoxicity.
Academic Article A phase I and pharmacodynamic study of the histone deacetylase inhibitor belinostat plus azacitidine in advanced myeloid neoplasia.
Academic Article Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.
Academic Article Are drug labels static or dynamic?
Academic Article Institutional Profile: University of Chicago Center for Personalized Therapeutics: research, education and implementation science.
Academic Article Germline variants and advanced colorectal adenomas: adenoma prevention with celecoxib trial genome-wide association study.
Academic Article Functional characterization of ABCC2 promoter polymorphisms and allele-specific expression.
Academic Article Unmet needs in preventing adverse drug-drug interactions.
Academic Article Conventional dosing of anticancer agents: precisely wrong or just inaccurate?
Academic Article Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).
Academic Article First-in-human phase I study of Lurbinectedin (PM01183) in patients with advanced solid tumors.
Academic Article Vatalanib population pharmacokinetics in patients with myelodysplastic syndrome: CALGB 10105 (Alliance).
Academic Article The development of a financial toxicity patient-reported outcome in cancer: The COST measure.
Academic Article Establishment of CYP2D6 reference samples by multiple validated genotyping platforms.
Academic Article Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liver.
Academic Article User beware: we need more science and less art when measuring financial toxicity in oncology.
Academic Article A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469.
Academic Article Re: Concordance between CYP2D6 genotypes obtained from tumor-derived and germline DNA.
Academic Article Glucuronidation of OTS167 in Humans Is Catalyzed by UDP-Glucuronosyltransferases UGT1A1, UGT1A3, UGT1A8, and UGT1A10.
Academic Article Redefining the primary objective of phase I oncology trials.
Academic Article Participation in Cancer Pharmacogenomic Studies: A Study of 8456 Patients Registered to Clinical Trials in the Cancer and Leukemia Group B (Alliance).
Academic Article First-in-human, phase I study of elisidepsin (PM02734) administered as a 30-min or as a 3-hour intravenous infusion every three weeks in patients with advanced solid tumors.
Academic Article Serum C-Telopeptide Collagen Crosslinks and Plasma Soluble VEGFR2 as Pharmacodynamic Biomarkers in a Trial of Sequentially Administered Sunitinib and Cilengitide.
Academic Article Impact of the 2010 Consensus Recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee.
Academic Article Harmonization of Renal Function Assessment Is Needed During Early Clinical Development of Oncology Drugs.
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for UGT1A1 and Atazanavir Prescribing.
Academic Article Analysis of Impact of Post-Treatment Biopsies in Phase I Clinical Trials.
Academic Article The Outlier in All of Us: Why Implementing Pharmacogenomics Could Matter for Everyone.
Academic Article Comparative Effects of CT Imaging Measurement on RECIST End Points and Tumor Growth Kinetics Modeling.
Academic Article Taking a Measured Approach to Toxicity Data in Phase I Oncology Clinical Trials.
Academic Article Casting doubt on the scientific utility of post-treatment biopsies in phase 1 trials.
Academic Article Reply to T.A. Yap et al.
Academic Article A randomized phase I trial of nanoparticle albumin-bound paclitaxel with or without mifepristone for advanced breast cancer.
Academic Article Disease-drug database for pharmacogenomic-based prescribing.
Academic Article Interferon Alfa-2b Antibodies and Clinical Resistance in a Patient with Hairy Cell Leukemia.
Academic Article Survival Experience of 195 Patients with Hairy Cell Leukemia Treated in a Multi-Institutional Study with Interferon-Alfa 2B.
Academic Article Low Dose Interferon Alfa-2B for the Induction of Remission of Hairy Cell Leukemia: A Multi-institutional Study of 49 Patients.
Academic Article Genomewide Association Studies in Pharmacogenomics: Meeting Report of the NIH Pharmacogenomics Research Network-RIKEN (PGRN-RIKEN) Collaboration.
Academic Article Measuring financial toxicity as a clinically relevant patient-reported outcome: The validation of the COmprehensive Score for financial Toxicity (COST).
Academic Article Interactions between MDM2 and TP53 Genetic Alterations, and Their Impact on Response to MDM2 Inhibitors and Other Chemotherapeutic Drugs in Cancer Cells.
Academic Article Drug-Drug Interactions With Oral Antineoplastic Agents.
Academic Article Pharmacogenetic Discovery in CALGB (Alliance) 90401 and Mechanistic Validation of a VAC14 Polymorphism that Increases Risk of Docetaxel-Induced Neuropathy.
Academic Article ABC transporter polymorphisms are associated with irinotecan pharmacokinetics and neutropenia.
Academic Article Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine.
Academic Article Patient Perceptions of Care as Influenced by a Large Institutional Pharmacogenomic Implementation Program.
Academic Article Food Effect Studies for Oncology Drug Products.
Academic Article Phase I study of lurbinectedin, a synthetic tetrahydroisoquinoline that inhibits activated transcription, induces DNA single- and double-strand breaks, on a weekly × 2 every-3-week schedule.
Academic Article The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems.
Academic Article Providing Balance in ASCO Clinical Practice Guidelines: CYP2D6 Genotyping and Tamoxifen Efficacy.
Academic Article A phase I study of XL184, a RET, VEGFR2, and MET kinase inhibitor, in patients (pts) with advanced malignancies, including pts with medullary thyroid cancer (MTC).
Academic Article A study of informed consent (IC), age, and cognitive performance (CP) among advanced cancer patients (acp) in phase I trials.
Academic Article Analysis of phase II studies for the year 2002: Design, conclusions and impact factors of oncology vs. non-oncology trials.
Academic Article A phase I trial of GRN163L (GRN), a first-in-class telomerase inhibitor, in advanced solid tumors.
Academic Article Cellular transporter pharmacogenetics in metastatic colorectal cancer: Initial analysis of C80203.
Academic Article Final findings from a phase II, placebo-controlled, randomized discontinuation trial (RDT) of sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC).
Academic Article Assessment of patient perceptions of genomic testing to inform pharmacogenomic implementation.
Academic Article Burdensome Research Procedures in Trials: Why Less Is More.
Academic Article Pharmacogenomics-Based Point-of-Care Clinical Decision Support Significantly Alters Drug Prescribing.
Academic Article Kinetic-Pharmacodynamic Model of Chemotherapy-Induced Peripheral Neuropathy in Patients with Metastatic Breast Cancer Treated with Paclitaxel, Nab-Paclitaxel, or Ixabepilone: CALGB 40502 (Alliance).
Academic Article Analyzing the clinical actionability of germline pharmacogenomic findings in oncology.
Academic Article Identification of a Genomic Region between SLC29A1 and HSP90AB1 Associated with Risk of Bevacizumab-Induced Hypertension: CALGB 80405 (Alliance).
Academic Article Metabolism of megestrol acetate in vitro and the role of oxidative metabolites.
Academic Article Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In Castration-Resistant Prostate Cancer.
Academic Article Genetic variation determines VEGF-A plasma levels in cancer patients.
Academic Article Do Patients With Advanced Cancer Have the Ability to Make Informed Decisions for Participation in Phase I Clinical Trials?
Academic Article Essential Characteristics of Pharmacogenomics Study Publications.
Academic Article A Pharmacogenetic Prediction Model of Progression-Free Survival in Breast Cancer using Genome-Wide Genotyping Data from CALGB 40502 (Alliance).
Academic Article Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy.
Academic Article The vitamin D receptor gene as a determinant of survival in pancreatic cancer patients: Genomic analysis and experimental validation.
Academic Article Fc-gamma receptor polymorphisms, cetuximab therapy, and overall survival in the CCTG CO.20 trial of metastatic colorectal cancer.
Academic Article Reply to I.F. Tannock, P. Isaacsson Velho et al, M. Tiako Meyo et al, and F.J.S.H. Woei-A-Jin et al.
Academic Article Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors.
Academic Article A pharmacodynamic study of sirolimus and metformin in patients with advanced solid tumors.
Academic Article Time Is Money: Optimizing the Scheduling of Nivolumab.
Academic Article Intraindividual Pharmacokinetic Variability: Focus on Small-Molecule Kinase Inhibitors.
Academic Article Clinical pharmacodynamic/exposure characterisation of the multikinase inhibitor ilorasertib (ABT-348) in a phase 1 dose-escalation trial.
Academic Article Genomic Heterogeneity Within Individual Prostate Cancer Foci Impacts Predictive Biomarkers of Targeted Therapy.
Academic Article Assessment of provider-perceived barriers to clinical use of pharmacogenomics during participation in an institutional implementation study.
Academic Article Patient-provider communications about pharmacogenomic results increase patient recall of medication changes.
Academic Article Immunotherapy and the A2A Adenosine Receptor: A Confounding Brew.
Academic Article Enhancing the Visibility and Prestige of Clinical Pharmacology as a Medical Subspecialty.
Academic Article Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy.
Academic Article Ethical Framework for Including Research Biopsies in Oncology Clinical Trials: American Society of Clinical Oncology Research Statement.
Academic Article Pharmacogenomic considerations for medications in the perioperative setting.
Academic Article The ImPreSS Trial: Implementation of Point-of-Care Pharmacogenomic Decision Support in Perioperative Care.
Academic Article Assessment of Patient Knowledge and Perceptions of Pharmacogenomics Before and After Using a Mock Results Patient Web Portal.
Academic Article Pharmacogenomic genotypes define genetic ancestry in patients and enable population-specific genomic implementation.
Academic Article Phase II randomised discontinuation trial of brivanib in patients with advanced solid tumours.
Academic Article A Cost-Focused Alternative Cancer Medication Dispensing Strategy-"Pack Splitting".
Academic Article Personalized Management of Chemotherapy-Induced Peripheral Neuropathy Based on a Patient Reported Outcome: CALGB 40502 (Alliance).
Academic Article A New Liver Expression Quantitative Trait Locus Map From 1,183 Individuals Provides Evidence for Novel Expression Quantitative Trait Loci of Drug Response, Metabolic, and Sex-Biased Phenotypes.
Academic Article Optimal Sampling Strategies for Irinotecan (CPT-11) and its Active Metabolite (SN-38) in Cancer Patients.
Academic Article Pharmacogenomic-Based Decision Support to Predict Adherence to Medications.
Academic Article Interventional Pharmacoeconomics: A Novel Mechanism for Unlocking Value.
Academic Article Clinical evaluation of germline polymorphisms associated with capecitabine toxicity in breast cancer: TBCRC-015.
Academic Article Safety, Clinical Activity, and Biological Correlates of Response in Patients with Metastatic Melanoma: Results from a Phase I Trial of Atezolizumab-Letter.
Academic Article Opportunities for using in silico-based extended dosing regimens for monoclonal antibody immune checkpoint inhibitors.
Academic Article Weight-Based Dosing of Pembrolizumab Every 6 Weeks in the Time of COVID-19.
Academic Article Applied Clinical Pharmacology in a Crisis: Interleukin-6 Axis Blockade and COVID-19.
Academic Article Genomewide Meta-Analysis Validates a Role for S1PR1 in Microtubule Targeting Agent-Induced Sensory Peripheral Neuropathy.
Academic Article COVIDOSE: Low-dose tocilizumab in the treatment of Covid-19.
Academic Article Genomic Analysis of Germline Variation Associated with Survival of Patients with Colorectal Cancer Treated with Chemotherapy Plus Biologics in CALGB/SWOG 80405 (Alliance).
Academic Article Patient insights on features of an effective pharmacogenomics patient portal.
Academic Article COVIDOSE: A Phase II Clinical Trial of Low-Dose Tocilizumab in the Treatment of Noncritical COVID-19 Pneumonia.
Academic Article Accelerated Approval of Anticancer Drugs: Lessons Learned From the Example of Olaratumab.
Academic Article Implementation of pharmacogenomic testing in oncology care (PhOCus): study protocol of a pragmatic, randomized clinical trial.
Academic Article Impact and applicability of pharmacogenomics in rheumatology: an integrated analysis.
Academic Article Near-Equivalence: Generating Evidence to Support Alternative Cost-Effective Treatments.
Academic Article Influence of N-acetyltransferase 2 gene polymorphisms on the in vitro metabolism of the epidermal growth factor receptor inhibitor rociletinib.
Academic Article Phase I Study of Stereotactic Body Radiotherapy plus Nivolumab and Urelumab or Cabiralizumab in Advanced Solid Tumors.
Academic Article Pharmacogenetic study in gastric cancer patients treated with adjuvant fluorouracil/leucovorin or epirubicin/cisplatin/fluorouracil before and after chemoradiation on CALGB 80101 (Alliance).
Academic Article Validation of a Large Custom-Designed Pharmacogenomics Panel on an Array Genotyping Platform.
Academic Article Appraisal and development of evidence-based clinical decision support to enable perioperative pharmacogenomic application.
Academic Article Negative innovation: when patents are bad for patients.
Academic Article Impact of CYP2D6 Pharmacogenomic Status on Pain Control Among Opioid-Treated Oncology Patients.
Academic Article Genome-wide association studies of survival in 1520 cancer patients treated with bevacizumab-containing regimens.
Academic Article Dose Optimization of Sotorasib: Is the US Food and Drug Administration Sending a Message?
Academic Article Underrepresented patient views and perceptions of personalized medication treatment through pharmacogenomics.
Academic Article Dose Optimization of Pembrolizumab: Less May Be More.
Academic Article Combination therapy patents: a new front in evergreening.
Academic Article Applicability of Pharmacogenomically Guided Medication Treatment during Hospitalization of At-Risk Minority Patients.
Academic Article Designing Dose-Finding Phase I Clinical Trials: Top Questions That Should Be Discussed With Your Clinical Pharmacologist.
Academic Article Clinically actionable genotypes for anticancer prescribing among >1500 patients with pharmacogenomic testing.
Academic Article Precision and Accuracy in the Brave New World of Basket Trials.
Academic Article Pilot Findings of Pharmacogenomics in Perioperative Care: Initial Results From the First Phase of the ImPreSS Trial.
Academic Article Alternative trastuzumab dosing strategies in HER2-positive early breast cancer are associated with patient out-of-pocket savings.
Academic Article Lurbinectedin-induced thrombocytopenia: the role of body surface area.
Academic Article Lorlatinib Exposed: A Far From Optimal Dose.
Academic Article Eftozanermin alfa (ABBV-621) monotherapy in patients with previously treated solid tumors: findings of a phase 1, first-in-human study.
Academic Article Two polymorphic gene loci associated with treprostinil dose in pulmonary arterial hypertension.
Academic Article The dosing of ibrutinib and related Bruton's tyrosine kinase inhibitors: eliminating the use of brute force.
Academic Article In Silico Re-Optimization of Atezolizumab Dosing Using Population Pharmacokinetic Simulation and Exposure-Response Simulation.
Academic Article Oncology phase I trial design and conduct: time for a change - MDICT Guidelines 2022.
Academic Article Implementation of pharmacogenomics into inpatient general medicine.
Academic Article US Government Payer-Funded Trials to Address Oncology's Drug-Dosing Conundrum: A Congressional Call to Action?
Concept Trastuzumab
Concept Pharmacogenomic Testing
Concept Regulatory Factor X Transcription Factors
Concept Equivalence Trials as Topic
Concept Peroxisome-Targeting Signal 1 Receptor
Concept Solute Carrier Organic Anion Transporter Family Member 1B3
Concept Tertiary Care Centers
Concept In Vitro Techniques
Concept Response Evaluation Criteria in Solid Tumors
Academic Article Patient-centered, self-funding dose optimization trials as a route to reduce toxicity, lower cost, and improve access to cancer therapy.
Academic Article Alternative Trastuzumab Dosing Schedules Are Associated With Reductions in Health Care Greenhouse Gas Emissions.
Academic Article Interventional pharmacoeconomics for immune checkpoint inhibitors through alternative dosing strategies.
Academic Article Combining atezolizumab 1200 mg with bevacizumab 15 mg/kg: based on science or just revenues?
Academic Article An Ethical and Financial Obligation for Sickle Cell Disease Gene Therapy in the United States.
Academic Article Common variation in a long non-coding RNA gene modulates variation of circulating TGF-ß2 levels in metastatic colorectal cancer patients (Alliance).
Academic Article Optimizing the doses of cancer drugs after usual dose finding.
Academic Article Gene signatures derived from transcriptomic-causal networks stratified colorectal cancer patients for effective targeted therapy.
Academic Article Pharmacogenetic and clinical risk factors for bevacizumab-related gastrointestinal hemorrhage in prostate cancer patients treated on CALGB 90401 (Alliance).
Academic Article Therapeutic Drug Monitoring of Oral Oncology Drugs: Another Example of Maslow's Hammer.
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